The ONE and ONLY ready-to-use* liquid zonisamide *Shake well before administering.

Medication
Transformed

Of the 20+ FDA-approved oral formulations of zonisamide, ZONISADETM is the ONLY alternative formulation to solid doses.1

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Zonisamide History

Zonisamide was first approved in the United States in 2000 as adjunctive therapy in the treatment of partial-onset seizures in adults with epilepsy.2

Quality & Reliability

Azurity medications comply with Current Good Manufacturing Practice (CGMP) regulations to help ensure consistency from pharmacy to pharmacy.3

Tailored Approach

Ready-to-use* oral liquids provide flexible dosing to meet a patient’s individual needs.
*Shake well before administering.

Product labeling, packaging, and imagery are for representation purposes only.

ZONISADETM is indicated for adjunctive therapy for the treatment of partial-onset seizures in adults and pediatric patients 16 years of age and older.

Oral liquids may help overcome certain barriers to treatment success

*ZONISADETM does not have head-to-head data on adherence.4

A calibrated measuring device is recommended to measure and deliver the prescribed dose accurately. A household teaspoon or tablespoon is not an adequate measuring device. Once opened, unused portion should be discarded after 30 days.

Finally, an alternative to zonisamide capsules

ZONISADETM, the ONE and ONLY FDA-approved ready-to-use* oral liquid zonisamide.

Adjunctive therapy for the management of epilepsy to support those who need additional medication

 

Long half-life enables once-daily dosing2

  • Patients who miss a dose should resume dosing at their next regularly scheduled dose—no makeup dose needed

Clinical trials have shown zonisamide to be well tolerated with a good safety profile, which is supported by an excess of 2 million patient-years of clinical exposure4

American Epilepsy Society Guidelines include zonisamide for use in treatment-resistant epilepsy based on Level A, B Recommendations5

  • Level A recommendations are established as effective to reduce seizure frequency
  • Level B recommendations should be considered to reduce seizure frequency

The ready-to-use* oral liquid formulation of ZONISADETM eliminates the need for crushing and compounding

  • Zonisamide powder can have a bitter taste6
  • Zonisamide is listed by the National Institute for Occupational Safety and Health (NIOSH) as a hazardous drug that may require safe handling guidance7

*Shake well before administering.

Cannot be used together with topiramate as adjunctive therapy.

After a single-dose administration, renal clearance of zonisamide is approximately 3.5 mL/min. The clearance of an oral dose of zonisamide from red blood cells is 2 mL/min. The elimination half-life of zonisamide in plasma is approximately 63 hours.

Did you know?


~34%

of FDA-sampled compounded products failed one or more standard quality tests performed, including potency testing.8
The ready-to-use* oral liquid formulation of ZONISADETM eliminates the need for compounding

Azurity medications comply with the FDA’s Current Good Manufacturing Practice (CGMP) guidelines, which regulate quality and purity of drugs.3

*Shake well before administering.

Strategies to improve adherence include pleasant-tasting medications and liquid formulations

ZONISADETM does not have head-to-head data on adherence.4

Did you know?


Disliking taste and difficulty swallowing were considered

barriers to clinical outcomes

for adolescent epilepsy patients.9

Did you know?


Survey results of 1051 adult general-practice patients with trouble swallowing revealed that 59% modified their drugs (splitting, crushing, opening capsules) to facilitate administration, and almost half were unaware it could affect safety and/or efficacy.10
The ready-to-use* oral liquid formulation of ZONISADETM eliminates the need for compounding7

*Shake well before administering.

The strawberry flavor of ZONISADETM may help enhance palatability

Did you know?


Zonisamide powder can have a bitter taste.6
Zonisamide is listed by the National Institute for Occupational Safety and Health (NIOSH) as a hazardous drug that may require safe handling guidance.7

Did you know?


Patients who miss a dose of ZONISADETM should resume dosing at their next regularly scheduled dose—no makeup dose needed.2
The long half-life of ZONISADETM enables once-daily dosing2

ZONISADETM: A tailored approach to dosing

Storage and administration

ZONISADETM can be stored at room temperature and should be protected from light.

ZONISADETM is a liquid suspension and should be shaken well before every administration. To administer directly into the mouth, it is important that ZONISADETM be measured with an accurate measuring device. A household teaspoon is not an accurate measuring device. Once opened, unused portions should be discarded after 30 days.

ZONISADETM should be administered once or twice daily with or without food. Its strawberry flavor may help enhance palatability.

ZONISADETM Conversion Calculator: Calculate mg to mL with precision

Dose:

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The recommended initial dose of ZONISADETM is 100 mg daily. The dosage may be increased by 100 mg daily every 2 weeks to 400 mg daily based on clinical response and tolerability. Patients who are tolerating ZONISADETM at 400 mg daily and require further reduction of seizures may be increased up to a maximum dosage of 600 mg daily. However, evidence from controlled trials shows no suggestion of increasing response above 400 mg/day.

ZONISADETM has a longer half-life of 105 hours, which allows for a once-daily dosing regimen and results in steady therapeutic drug levels. This means that if a patient misses a dose, they can resume dosing at the regular schedule without a makeup dose.2

Dosing for Patients Aged 16 Years and Older*
Initial dose 100 mg daily
Beyond 2 weeks May be increased by 100 mg/day every 2 weeks to 400 mg/day†,‡
  • ZONISADETM may be administered once or twice daily with or without food
  • Safety and efficacy in pediatric patients below 16 years of age have not been established

*Measure with an accurate measuring device. A household teaspoon is not an accurate measuring device.

Based on clinical response and tolerability.

Patients who are tolerating 400 mg/day and require further reduction of seizures may be increased up to a maximum dosage of 600 mg/day.
However, evidence from controlled trials shows no suggestion of increasing response above 400 mg/day.

Visit MedicationTransformed.com to learn about other liquid formulations from Azurity.

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